Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?

 1.Sickle cell disease is an adaptive response against malaria. Discuss and identify the pathogen and transmission of malaria.

2. Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?

3. Why do people who no longer live in parts of the world where malaria is prevalent still develop sickle cell disease and how and why does it occur?

4.How can we advise families with this debilitating disease?

RUBRIC

1. Resources are to be sited. If it is not your original thought or idea you must give credit to the author, if not sited it  is considered plagiarism.

2. Resources are not to be older than 5 years old and it must be scholarly peer reviewed journals!

3. All written material must be in APA format. Please use the latest manual. Points will be deducted as per rubic if not done correctly.

4. Please expand your ideas and add your thought to your writing. Why did you use that resources? What will this quote add to the discussion?

 You are now at the master’s level, you can agree or disagree with the author. Your opinion and experience counts!

Sample Solution

1. Malaria is a disease caused by the parasite Plasmodium, which is transmitted by the bite of infected Anopheles mosquitoes. The pathogen multiplies within the red blood cells of the host, causing symptoms such as fever, chills, and anemia.
2. The adaptation of sickle cell disease is thought to have occurred in populations where malaria was prevalent, as individuals with the sickle cell trait have a reduced risk of severe malaria. The pathophysiology of the adaptation involves a mutation in the gene that codes for the beta-globin subunit of hemoglobin, resulting in the production of hemoglobin molecules that can form rigid, sickle-shaped red blood cells.
3. Sickle cell disease still occurs in populations who no longer live in areas where malaria is prevalent due to genetic mutations being passed down through families. It occurs as a result of inheriting two copies …Order a customized and more comprehensive answer here