Sickle cell disease is an adaptive response against malaria.

 1.Sickle cell disease is an adaptive response against malaria. Discuss and identify the pathogen and transmission of malaria.

2. Where and why do you think an adaptation occurred that led to the development of sickle cell disease and what is the pathophysiology of the adaptation?

3. Why do people who no longer live in parts of the world where malaria is prevalent still develop sickle cell disease and how and why does it occur?

4.How can we advise families with this debilitating disease?

RUBRIC

1. Resources are to be sited. If it is not your original thought or idea you must give credit to the author, if not sited it  is considered plagiarism.

2. Resources are not to be older than 5 years old and it must be scholarly peer reviewed journals!

3. All written material must be in APA format. Please use the latest manual. Points will be deducted as per rubic if not done correctly.

4. Please expand your ideas and add your thought to your writing. Why did you use that resources? What will this quote add to the discussion?

   You are now at the master’s level, you can agree or disagree with the author. Your opinion and experience counts!

Sample Solution

1. Malaria is a parasitic disease caused by Plasmodium species, transmitted to humans through the bites of infected Anopheles mosquitoes. It affects millions of people worldwide, mainly in tropical and subtropical regions.
2. The sickle cell trait is thought to have originated in regions of sub-Saharan Africa where malaria was endemic. The mutation in the gene for hemoglobin causes the formation of abnormal hemoglobin molecules that tend to form rigid, sickle-shaped red blood cells. This shape allows the red blood cells to better withstand destruction by the malaria parasite. This adaptation provided a survival advantage to individuals carrying the sickle cell trait and increased the frequency of the mutation in populations where malaria was common.
3. Although sickle cell disease is most commonly found in individuals of African descent, it is also found in other populations, including people of Mediterranean, Middle Eastern, and Asian ancestry. The disease occurs when an individual inherits two copies of the mutated hemoglobin gene, one from each parent. Even individuals who no longer live in areas where malaria is prevalent still develop the disease due to the high frequency of the mutation in certain populations.
4. Individuals with sickle cell disease can receive comprehensive care from a multidisciplinary healthcare team, including regular check-ups, preventive measures, and treatment for complications. Family education and support are also important for managing the disease. Additionally, individuals with sickle …Order a customized and more comprehensive answer here