HOMEWORK HELP | Discuss the clotting mechanism.

A 30 year old male presents with acute trauma. The final diagnosis is DIC (Disseminated Intravascular Coagulation).

1- Discuss the clotting mechanism.
2- What do prolonged PT and aPTT tests evaluate?
3- Fibrin degradation and split products are common to DIC patients. Why?
4- Identify two additional conditions that can initiate DIC and how?

MODEL ANSWER

Case study on Disseminated Intravascular Coagulation

Blood is an important component in the human body, and its loss may be a scare to one’s life. All measures possible must be put up to prevent the loss of blood. The human body will often protect against the loss of blood by the process of clotting. This task critically evaluates the process of blood clotting as will be evaluated in this task.

The Process of Blood Clotting

The process of blood clotting can be divided into primary and secondary hemostasis. The primary hemostasis is as a result of the formation of a platelet plug that is weak and can be achieved through four stages. Vasoconstriction where blood flow is slowed at the place of injury allowing the formation of | PLACE YOUR ORDER NOW AT writtask.com | can occur as a result of platelet adhesion where the subendothelial matrix proteins bind together. It can as well occur as a result of platelet activation and aggregation where blood platelets clump together within the blood to form a clot (Gaertner & Massberg, 2016). For secondary hemostasis, clotting factors are activated and are converted from prothrombin to thrombin and the conversion of fibrinogen to fibrin.

What Prolonged PT and aPTT tests Evaluate

PT is a blood test which evaluates the time taken for a blood clot to form. It can also be used to identify bleeding | PLACE YOUR ORDER NOW AT writtask.com | the other hand, is a screening test used to measure the ability of a person to form blood clots (Ilinskaya & Dobrovolskaia, 2016).

Why Fibrin Degradation and Split Products are Common among Patients with DIC

Fibrin degradation and split products are often associated with DIC patients since such patients have high clotting, which eventually depletes and other clotting | PLACE YOUR ORDER NOW AT writtask.com | of fibrin threads and fragments of protein will be released to their bodies.

Conditions that can Initiate DIC and how

Many conditions can lead to DIC among | PLACE YOUR ORDER NOW AT writtask.com | is blood transfusion when a person’s immune system destroys the transfused red blood cells in a process called | PLACE YOUR ORDER NOW AT writtask.com | second condition is when there is a bacterial or fungal infection in a | PLACE YOUR ORDER NOW AT writtask.com | that often travel to the injury site to help alleviate bleeding can become extremely active, leading to DIC. 

References

Gaertner, F., & Massberg, S. (2016, December). Blood coagulation in immunothrombosis—At the frontline of intravascular immunity. In Seminars in immunology (Vol. 28, No. 6, pp. 561-569). Academic Press.

Ilinskaya, A. N., & Dobrovolskaia, M. A. (2016). Nanoparticles and the blood coagulation system. In handbook of immunological properties of engineered nanomaterials: Volume 2: Haematocompatibility of Engineered Nanomaterials (pp. 261-302).