Begin by selecting a topic pertaining to genes and gene-environment interaction from one of the following resources:
Refer to chapters 4 and 5 of your text (Pathophysiology 7th edition
The Biologic Basis for Disease in Adults and Children by Kathryn L McCance Sue E Huether), unit II
Select a topic from the list below
Look for ideas in the WCU Library databases
Conduct a literature search of recent journal articles (peer reviewed) within the last three years that pertain to your topic. You must select three articles for this assignment.
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Synthesize the knowledge gained from the chapter readings and your literature research into a comprehensive understanding of the topic.
Explain and evaluate the data, assertions, findings, and/or claims made in the literature.
Identify any evidence-based support for the claims made in the literature.
Draw and summarize your own unique conclusions based on a comprehensive understanding of the topic and your research.
Topic: Consider the familial tendencies and contributing environmental factors (nature/nurture debate) in coronary artery disease (CAD).
Include at least three scholarly sources in your paper in addition to citing the course etext.
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Use APA format to style your paper and to cite your sources. Your source(s) should be integrated into the paragraphs. Use internal citations pointing to evidence in the literature and supporting your ideas. You will need to include a reference page listing those sources.
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Familial tendencies refer to the health conditions or diseases that occur in several family generations from different generations but do not have a proven | PLACE YOUR ORDER NOW AT writtask.com | fall under familial tendencies tend to affect multiple members of a given family, hence making them likely to suffer from the same problem in the future. In some cases, the disease occurs due to genetic mutations but in most instances, the people from the same family suffer from the disease because they are exposed to the same | PLACE YOUR ORDER NOW AT writtask.com | is a condition that falls in the familial tendency category of diseases. CAD is a disease that causes a buildup in the amount of cholesterol-laden deposits in an individual’s arteries, which makes it among the most prevalent life-threatening heart | PLACE YOUR ORDER NOW AT writtask.com | not only get blocked by the cholesterol but also have inflammation, causing them to narrow and hence decrease the amount of blood that | PLACE YOUR ORDER NOW AT writtask.com | major organs of the body such as the…
Genetics
One major cause of CAD is genetics. The disease has been proven to have an inheritability rate of between 40-60 percent, depending on the family. According to a study conducted by the Framingham Offspring Study in Sweden, people with a family history of CAD, are likely to suffer from the disease. Subjects featured in the study continued to have follow-ups for over ten years to pinpoint at what age they developed the disease. The research data collected shows that the disease tends to showcase heritable effects in younger individuals. The genetic | PLACE YOUR ORDER NOW AT writtask.com |
While there is still a lot to learn about the disease, there are several genome markers that are directly associated with CAD. An individual is likely to suffer from CAD, when they have high levels of the low-density lipoprotein (LDL), also commonly known as bad | PLACE YOUR ORDER NOW AT writtask.com | can affect a person’s LDL levels some of which include their lifestyle choices, underlying conditions, and genetics. The higher the levels of LDL, the higher the risk of | PLACE YOUR ORDER NOW AT writtask.com | the genetic markers linked to the high cholesterol levels include LDLR, NCAN, PCSK9, HMGCR, and MAFB. These genetic markers tend to control the lipid metabolism pathway in the body along with lipid transport and packaging which are vital to the cholesterol | PLACE YOUR ORDER NOW AT writtask.com | component to look out for is the triglycerides. The genes associated with the varying levels of triglycerides include MLXIPL, LPL, PTLP, ANGPTL3, and FADS1. These genes tend to encode a transcription factor that affects various aspects of bodily functions such as lipogenesis and glycolysis (Shukla et al., 2018). The continual polymorphisms in these genes, tend to change the rate of triglyceride…
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