Assignment Help: Conduct an evidence-based drug search on the drug you selected and post an explanation of any possible issues.

Frankenstein, L., Katus, H. A., Grundtvig, M., Hole, T., de Blois, J., Schellberg, D., … Agewall, S. (2013). Association between spironolactone added to beta-blockers and ACE inhibition and survival in heart failure patients with reduced ejection fraction: A propensity score-matched cohort study. European Journal of Clinical Pharmacology, 69(10), 1747–1755.

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All of the following groups of medications are commonly prescribed in the acute care setting. Choose one of the topics below to discuss. If it is a medication group, select a specific drug within that group. (This is a good way to prepare for clinical practice, because you will get to know the drugs you will prescribe for patients.). Focus your discussion on the hospital or ICU setting and IV usage.

1. ACE versus BBlocker with spironolactone in CHF

Option 2

Conduct an evidence-based drug search on the drug you selected and post an explanation of any possible issues. Are there any drug interactions? Any black box warnings? To what type of patient would you prescribe this medication?

SAMPLE SOLUTION

Discussion 1 part 2

ACE versus BBlocker with spironolactone in CHF

The ACE inhibitor is a group of antihypertensive medication that helps in the relaxation of arteries and leads to renal excretion of salt and water by stopping or reducing the activity of angiotensin converting enzyme. Generally, ACE inhibitors are pharmacology medication that slows the ACE enzymes decreasing angiotensin production which leads to expansion of blood vessels. The medicines are essential to prevent early death as a result of

The use of ACE together with potassium supplements, salt diuretics like Spironolactone which increase potassium levels in the blood can lead to excess potassium levels. The combination of ACE inhibitors and spironolactone to manage CHF can also cause dangerous hyperkalaemia (Frankenstein et al., 2013). Therefore, in case the drugs are used in combination with captopril, it is essential that potassium levels are monitored to avoid complications on the body. The drug can also interact with lithium which when not observed correctly it can lead to toxicity (Raimondi et al., 2016). Furthermore

Consumption of captopril has its side effects where most have been confirmed mild and transient. For instance, after using the medication, a persistent dry cough can result when an individual stops taking the drug. Wrong use of the medication can lead to kidney failure and increased potassium levels in the blood (Cheng et al., 2014). It is, therefore, essential that an individual uses the medicines under the instructions of a legalized and experienced medical practitioner. Diarrhoea, dizziness, and nausea are noticed by some patients when they start using the BBlocker (Frankenstein et al., 2013). The medication should be taken by individuals with conditions such as high blood pressure and heart failure. It is also a preventive medication for the kidney failure condition, a situation that arises because of high