One of the more common biology analogies refers to cells as the “building blocks” of life. This rightfully places an emphasis on understanding cells, cellular behavior, and the impact of the environment in which they function.
Such an understanding helps explain how healthy cell activity contributes to good health. Just as importantly, it helps explain how breakdowns in cellular behavior and alterations to cells lead to health issues.
This week, you examine cellular processes that are subject to alterations that can lead to disease. You evaluate the genetic environments within which these processes exist as well as the impact these environments have on disease.
• Evaluate cellular processes and alterations within cellular processes
• Evaluate the impact of the genetic environment on disease
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Learning Resources
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Write My Essay For MeMcCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.
• Chapter 1: Cellular Biology; Summary Review
• Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents (pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review
• Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases
• Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review
• Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review
• Chapter 7: Innate Immunity: Inflammation and Wound Healing
• Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review
• Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review
• Chapter 10: Infection (pp. 289–303; stop at Infectious parasites and protozoans); (start at HIV); Summary Review
• Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review
• Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review
• Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review
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Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/
Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls
A 27-year-old patient with a history of substance abuse is found unresponsive by emergency medical services (EMS) after being called by the patient’s roommate. The roommate states that he does not know how long the patient had been lying there. Patient received naloxone in the field and has become responsive. He complains of burning pain over his left hip and forearm. Evaluation in the ED revealed a large amount of necrotic tissue over the greater trochanter as well as the forearm. EKG demonstrated prolonged PR interval and peaked T waves. Serum potassium level 6.9 mEq/L.
For this Discussion, you will examine the above case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts.
Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:
• The role genetics plays in the disease.
• Why the patient is presenting with the specific symptoms described.
• The physiologic response to the stimulus presented in the scenario and why you think this response occurred.
• The cells that are involved in this process.
• How another characteristic (e.g., gender, genetics) would change your response.
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_Rubric
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Excellent Good Fair Poor
Main Posting 45 (45%) – 50 (50%)
Answers all parts of the Discussion question(s) with reflective critical analysis and synthesis of knowledge gained from the course readings for the module and current credible sources.
Supported by at least three current, credible sources.
Written clearly and concisely with no grammatical or spelling errors and fully adheres to current APA manual writing rules and style.
This is Rhabdomyolysis due to fall from Drug intoxication.
MODEL ANSWER
The disease highlighted in the case study scenario is Rhabdomyolysis due to fall from | PLACE YOUR ORDER NO witnessed on the left arm as well as the hip area and the examination of necrotic tissue on the larger trochanter and the forearm also points at | PLACE YOUR ORDER NO is also commonly linked to drug abuse and it results to elevated serum potassium levels of 6.9m Eq/L which shows presence of hyperkalemia.
Genetics plays a significant role in the disease. Some of the genetic causes of the condition include metabolic myopathy, the disorders of the intermuscular calcium release, muscular dystrophies and the mitochondrial | PLACE YOUR ORDER NOW AT writtask.com | muscle defects are also associated with the condition due to the inability of such muscles to appropriately utilize ATP. Such occurrences are often genetically instigated (Justiz-Vaillant & Zito, 2019).
There are many notable symptoms presented by the patient. First is the burning sensation over the left hip as well as the forearm as a result of necrosis within | PLACE YOUR ORDER NOW AT writtask.com | possibly used as the injection cites that result in rhabdomyolysis. The patient was initially unresponsive from the opioid overdose that led to difficulty in breathing. The breathing was only possible | PLACE YOUR ORDER NOW AT writtask.com | .
The physiological response to the stimuli as presented in the scenario include the patient being responsive after being given naloxone since it is a non-selective and competitive opioid that reverses the depressive nature of the central nervous system as well as the respiratory system occasioned by the | PLACE YOUR ORDER NOW AT writtask.com |
The cells that are involved in the process are the muscle cells which release the toxic intracellular components into the systemic circulation leading to disturbance of the | PLACE YOUR ORDER NOW AT writtask.com | such as gender would not have changed the response since genetic characteristics of the condition are | PLACE YOUR ORDER NOW AT writtask.com |
References
Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK513315/
Kruijt, N., van den Bersselaar, L. R., Kamsteeg, E. J., Verbeeck, W., Snoeck, M. M. J., Everaerd, D. S., … & Voermans, N. C. (2021). The etiology of rhabdomyolysis: an interaction between genetic susceptibility and external triggers. European Journal of Neurology, 28(2), 647-659.
McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.
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