Maria is a 19-year-old exchange student from Brazil. She was started on daily isoniazid (INH) 4 months ago for latent tuberculosis (TB). She would like to be seen at your clinic now because it is closer to school. She has not taken her medication for 4 weeks and cannot recall when her labs were drawn last. She has no other health history and does not take any other medications. According to the national guidelines, how long would Maria likely need to take INH? Can she restart her medication even though she has been off for 1 month? How often should she be seen for follow-up? What are the black box warnings of INH?
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The National guidelines contend that Maria will have to take Isoniazid (INH) monotherapy at least for either | PLACE YOUR ORDER NOW AT writtask.com | however recommend that patients in the position of Maria are subjected to the 9-month regimen. Besides Isoniazid, it is also recommended that INH and Rifapentine can be combined and taken for | PLACE YOUR ORDER NOW AT writtask.com | can restart her medication even after being off the medication | PLACE YOUR ORDER NOW AT writtask.com | is known to stay in the body for a long time and can easily turn into an active TB disease. Besides, the condition can at times result into a liver condition if not well addressed.
Although she is justified to restart the medication, the liver enzymes need to be checked to evaluate the | PLACE YOUR ORDER NOW AT writtask.com | also need to be done to help assess the state of the infection since it is possible that the infection could have progressed to a very active state when she stopped taking the | PLACE YOUR ORDER NOW AT writtask.com | might have developed resistance to the INH when she failed to complete the initial treatment. These assessments are key in defining progressive treatment regimens.
Follow-up is an important aspect in trying to contain the TB virus. Maria should visit a doctor at least once in a month to assess how the | PLACE YOUR ORDER NOW AT writtask.com | INH is hepatoxic and requires close monitoring. Some of the black box warnings include avoiding alcohol as much as possible when taking | PLACE YOUR ORDER NOW AT writtask.com | is often associated with fatal hepatitis which means that the patient should be enlightened on the possible signs of hepatitis and how to avoid the condition (Hu et al., 2017). Additionally, the medications that are hepatotoxic need to be avoided.
References
Churchyard, G. J., & Swindells, S. (2019). Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB. PLoS Medicine, 16(4), e1002787.
Hu, Y. Q., Zhang, S., Zhao, F., Gao, C., Feng, L. S., Lv, Z. S., … & Wu, X. (2017). Isoniazid derivatives and their anti-tubercular activity. European Journal of Medicinal Chemistry, 133, 255-267.
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