A 78-year-old woman with a history of anxiety and hypertension presented to our family medicine residency practice in Massachusetts with subacute polyarticular arthralgias that had been present for 2 months. She complained of pain and swelling of both ankles and the right knee. She noted that her symptoms had started on a recent trip to the Dominican Republic, where she developed generalized joint pain and a fever that lasted 1 to 2 weeks and subsequently resolved with the lingering polyarthralgia. She denied any rash, constitutional symptoms, photosensitivity, headaches, photophobia, or history of tick bite. Physical examination revealed normal vital signs, notable warmth and swelling of the bilateral ankles that was worse on the right side, and swelling of the right knee with effusion—but no tenderness—to palpation.
Possible Diagnosis with rationale explanation. At least 3 differentials must be mentioned with rationales explanation.
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- Lyme Disease: This diagnosis is possible given the patient’s history of a recent trip to the Dominican Republic, which is a known endemic region for Lyme disease, and her presenting symptoms of polyarticular arthralgias. The patient’s history of fever and joint pain further support the consideration of this differential. The physical exam would help to further confirm or rule out this diagnosis.
- Rheumatoid Arthritis: This is a possible differential given the patient’s history of polyarticular arthralgias and the presence of joint swelling and effusion. Additionally, patients with rheumatoid arthritis may present with constitutional symptoms such as fatigue, low-grade fever, and weight loss, which the patient did not report.
- Gout: Gout is a possible differential as it can present with polyarticular arthralgias, particularly in the ankles and knees. The patient’s history of recent travel to the Dominican Republic may have been a triggering factor for this condition. Further investigation into her medical history and laboratory testing would help to …ORDER A COSTOMIZED AND COMPREHENSIVE ANSWER. CLICK HERE



